Reaction Details |
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Target | Endothelin-1 receptor |
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Ligand | BDBM50057153 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_63194 (CHEMBL679797) |
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IC50 | 1.1±n/a nM |
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Citation | Patt, WC; Edmunds, JJ; Repine, JT; Berryman, KA; Reisdorph, BR; Lee, C; Plummer, MS; Shahripour, A; Haleen, SJ; Keiser, JA; Flynn, MA; Welch, KM; Reynolds, EE; Rubin, R; Tobias, B; Hallak, H; Doherty, AM Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists. J Med Chem40:1063-74 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-1 receptor |
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Name: | Endothelin-1 receptor |
Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48736.88 |
Organism: | Homo sapiens (Human) |
Description: | P25101 |
Residue: | 427 |
Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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BDBM50057153 |
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n/a |
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Name | BDBM50057153 |
Synonyms: | CHEMBL10832 | Sodium; (Z)-2-benzo[1,3]dioxol-5-yl-4-(4-methoxy-phenyl)-4-oxo-3-(2,3,4-trimethoxy-benzyl)-but-2-enoate |
Type | Small organic molecule |
Emp. Form. | C28H25O9 |
Mol. Mass. | 505.4932 |
SMILES | COc1ccc(cc1)C(=O)C(\Cc1ccc(OC)c(OC)c1OC)=C(/C([O-])=O)c1ccc2OCOc2c1 |
Structure |
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