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TargetEndothelin-1 receptor
LigandBDBM50057153
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63194 (CHEMBL679797)
IC50 1.1±n/a nM
Citation Patt, WCEdmunds, JJRepine, JTBerryman, KAReisdorph, BRLee, CPlummer, MSShahripour, AHaleen, SJKeiser, JAFlynn, MAWelch, KMReynolds, EERubin, RTobias, BHallak, HDoherty, AM Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists. J Med Chem40:1063-74 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Endothelin-1 receptor
Name:Endothelin-1 receptor
Synonyms:EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:Enzyme Catalytic Domain
Mol. Mass.:48736.88
Organism:Homo sapiens (Human)
Description:P25101
Residue:427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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  Blast E-value cutoff:
BDBM50057153
n/a
NameBDBM50057153
Synonyms:CHEMBL10832 | Sodium; (Z)-2-benzo[1,3]dioxol-5-yl-4-(4-methoxy-phenyl)-4-oxo-3-(2,3,4-trimethoxy-benzyl)-but-2-enoate
TypeSmall organic molecule
Emp. Form.C28H25O9
Mol. Mass.505.4932
SMILESCOc1ccc(cc1)C(=O)C(\Cc1ccc(OC)c(OC)c1OC)=C(/C([O-])=O)c1ccc2OCOc2c1
Structure
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