| Reaction Details |
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 | Report a problem with these data |
| Target | Nitroreductase NfsA |
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| Ligand | BDBM50057440 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_206006 (CHEMBL840569) |
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| IC50 | 4000±n/a nM |
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| Citation |  Friedlos, F; Denny, WA; Palmer, BD; Springer, CJ Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy. J Med Chem40:1270-5 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nitroreductase NfsA |
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| Name: | Nitroreductase NfsA |
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| Synonyms: | Modulator of drug activity A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 26851.30 |
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| Organism: | Escherichia coli O157:H7 |
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| Description: | ChEMBL_206006 |
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| Residue: | 240 |
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| Sequence: | MTPTIELTCGHRSIRHFTDEPISEAQREAIINSARATSSSSFLQCSSIIRITDKALREEL
VTLTGGQKHVAQAAEFWVFCADFNRHLQICPDAQLGLAEQLLLGVVDTAMMAQNALTAAE
SLGLGGVYIGGLRNNIEAVTKLLKLPQHVLPLFGLCLGWPADNPDLKPRLPSSILVHENS
YQPLDKDALAQYDEQLAEYYLTRGSNNRRDTWSDHIRRTIIKESRPFILDYLHKQGWATR
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| BDBM50057440 |
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| n/a |
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| Name | BDBM50057440 |
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| Synonyms: | 2-[Bis-(2-iodo-ethyl)-amino]-N-(2,3-dihydroxy-propyl)-3,5-dinitro-benzamide | CHEMBL23938 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H18I2N4O7 |
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| Mol. Mass. | 608.1243 |
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| SMILES | OCC(O)CNC(=O)c1cc(cc(c1N(CCI)CCI)[N+]([O-])=O)[N+]([O-])=O |
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| Structure | 
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