| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50057819 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_197125 (CHEMBL803726) |
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| EC50 | 1500±n/a nM |
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| Citation |  Adams, DR; Perez, C; Maillard, M; Florent, JC; Evers, M; Hénin, Y; Litvak, S; Litvak, L; Monneret, C; Grierson, DS Preparation and anti-HIV activity of N-3-substituted thymidine nucleoside analogs. J Med Chem40:1550-8 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50057819 |
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| n/a |
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| Name | BDBM50057819 |
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| Synonyms: | 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-3-(2,2-diethoxy-ethyl)-5-methyl-1H-pyrimidine-2,4-dione | CHEMBL39874 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H25N5O6 |
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| Mol. Mass. | 383.3996 |
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| SMILES | CCOC(Cn1c(=O)c(C)cn(C2CC(N=[N+]=[N-])C(CO)O2)c1=O)OCC |
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| Structure | 
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