Reaction Details | |||
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Target | Serine protease 1 | ||
Ligand | BDBM50057828 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_212861 (CHEMBL817813) | ||
Ki | 94±n/a nM | ||
Citation | Tucker, TJ; Lumma, WC; Lewis, SD; Gardell, SJ; Lucas, BJ; Baskin, EP; Woltmann, R; Lynch, JJ; Lyle, EA; Appleby, SD; Chen, IW; Dancheck, KB; Vacca, JP Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy. J Med Chem40:1565-9 (1997) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine protease 1 | |||
Name: | Serine protease 1 | ||
Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 26557.80 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P07477 | ||
Residue: | 247 | ||
Sequence: |
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BDBM50057828 | |||
n/a | |||
Name | BDBM50057828 | ||
Synonyms: | (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide | CHEMBL416795 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H36N4O2 | ||
Mol. Mass. | 448.6003 | ||
SMILES | N[C@H](C(c1ccccc1)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC1CCC(N)CC1 |wU:21.24,wD:1.0,(8.37,-6.36,;9.7,-5.59,;9.7,-4.05,;11.04,-3.28,;12.58,-3.28,;13.35,-1.94,;12.56,-.61,;11.02,-.62,;10.27,-1.96,;8.35,-3.28,;8.35,-1.74,;7.03,-.97,;5.69,-1.74,;5.69,-3.28,;7.03,-4.05,;11.05,-6.36,;11.05,-7.9,;12.36,-5.59,;12.52,-4.05,;14.03,-3.73,;14.8,-5.05,;13.77,-6.2,;14.1,-7.71,;12.96,-8.74,;15.57,-8.18,;16.72,-7.15,;18.17,-7.61,;18.09,-8.95,;19.1,-10.37,;17.98,-11.46,;19.06,-12.54,;18.09,-10.21,;17.07,-8.71,)| | ||
Structure |