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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50058164 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_51280 (CHEMBL664982) | ||
| IC50 | 7.6±n/a nM | ||
| Citation |  Chen, YL; Mansbach, RS; Winter, SM; Brooks, E; Collins, J; Corman, ML; Dunaiskis, AR; Faraci, WS; Gallaschun, RJ; Schmidt, A; Schulz, DW Synthesis and oral efficacy of a 4-(butylethylamino)pyrrolo[2,3-d]pyrimidine: a centrally active corticotropin-releasing factor1 receptor antagonist. J Med Chem40:1749-54 (1997) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 47870.75 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | Receptor binding assays were performed using rat cortex homogenate. | ||
| Residue: | 415 | ||
| Sequence: |
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| BDBM50058164 | |||
| n/a | |||
| Name | BDBM50058164 | ||
| Synonyms: | But-2-enyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-ethyl-amine | CHEMBL300935 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H30N4 | ||
| Mol. Mass. | 362.5111 | ||
| SMILES | CCN(C\C=C\C)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(7.05,-2.18,;6.86,-3.71,;5.44,-4.3,;4.32,-3.2,;2.85,-3.59,;1.76,-2.5,;.26,-2.9,;5.44,-5.84,;4.11,-6.61,;4.11,-8.15,;2.78,-8.92,;5.44,-8.92,;6.77,-8.15,;8.24,-8.63,;9.15,-7.38,;8.24,-6.12,;8.72,-4.67,;6.77,-6.61,;8.73,-10.1,;7.7,-11.23,;6.19,-10.92,;8.17,-12.7,;9.67,-13.02,;10.16,-14.49,;10.71,-11.86,;10.23,-10.41,;11.25,-9.26,)| | ||
| Structure | 
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