Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50058167 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_51280 (CHEMBL664982) | ||
IC50 | 110±n/a nM | ||
Citation | Chen, YL; Mansbach, RS; Winter, SM; Brooks, E; Collins, J; Corman, ML; Dunaiskis, AR; Faraci, WS; Gallaschun, RJ; Schmidt, A; Schulz, DW Synthesis and oral efficacy of a 4-(butylethylamino)pyrrolo[2,3-d]pyrimidine: a centrally active corticotropin-releasing factor1 receptor antagonist. J Med Chem40:1749-54 (1997) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1 | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 47870.75 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | Receptor binding assays were performed using rat cortex homogenate. | ||
Residue: | 415 | ||
Sequence: |
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BDBM50058167 | |||
n/a | |||
Name | BDBM50058167 | ||
Synonyms: | Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine | CHEMBL296977 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H28N4 | ||
Mol. Mass. | 336.4738 | ||
SMILES | CCCCNc1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-1.47,2.21,;.02,2.6,;1.1,1.51,;2.59,1.9,;3.69,.81,;3.7,-.73,;2.38,-1.51,;2.38,-3.05,;1.03,-3.82,;3.7,-3.82,;5.04,-3.05,;6.51,-3.53,;7.42,-2.27,;6.51,-1.02,;6.97,.43,;5.04,-1.5,;6.99,-4.99,;8.48,-5.3,;9.5,-4.15,;8.95,-6.76,;7.93,-7.91,;8.41,-9.37,;6.43,-7.58,;5.95,-6.13,;4.43,-5.81,)| | ||
Structure |