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TargetCorticotropin-releasing factor receptor 1
LigandBDBM50058167
Substrate/Competitorn/a
Meas. Tech.ChEMBL_51280 (CHEMBL664982)
IC50 110±n/a nM
Citation Chen, YLMansbach, RSWinter, SMBrooks, ECollins, JCorman, MLDunaiskis, ARFaraci, WSGallaschun, RJSchmidt, ASchulz, DW Synthesis and oral efficacy of a 4-(butylethylamino)pyrrolo[2,3-d]pyrimidine: a centrally active corticotropin-releasing factor1 receptor antagonist. J Med Chem40:1749-54 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Corticotropin-releasing factor receptor 1
Name:Corticotropin-releasing factor receptor 1
Synonyms:CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:47870.75
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat cortex homogenate.
Residue:415
Sequence:
MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEV
HQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPF
PIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
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  Blast E-value cutoff:
BDBM50058167
n/a
NameBDBM50058167
Synonyms:Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine | CHEMBL296977
TypeSmall organic molecule
Emp. Form.C21H28N4
Mol. Mass.336.4738
SMILESCCCCNc1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-1.47,2.21,;.02,2.6,;1.1,1.51,;2.59,1.9,;3.69,.81,;3.7,-.73,;2.38,-1.51,;2.38,-3.05,;1.03,-3.82,;3.7,-3.82,;5.04,-3.05,;6.51,-3.53,;7.42,-2.27,;6.51,-1.02,;6.97,.43,;5.04,-1.5,;6.99,-4.99,;8.48,-5.3,;9.5,-4.15,;8.95,-6.76,;7.93,-7.91,;8.41,-9.37,;6.43,-7.58,;5.95,-6.13,;4.43,-5.81,)|
Structure
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