| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-dependent protein kinase |
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| Ligand | BDBM6760 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_161879 (CHEMBL770262) |
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| IC50 | 0.016000±n/a nM |
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| Citation |  Kaneko, M; Saito, Y; Saito, H; Matsumoto, T; Matsuda, Y; Vaught, JL; Dionne, CA; Angeles, TS; Glicksman, MA; Neff, NT; Rotella, DP; Kauer, JC; Mallamo, JP; Hudkins, RL; Murakata, C Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives. J Med Chem40:1863-9 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-dependent protein kinase |
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| Name: | cAMP-dependent protein kinase |
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| Synonyms: | Cyclic AMP-dependent protein kinase (PKA) | PKA catalytic subunit alpha | Serine/threonine-protein kinase | cAMP-dependent protein kinase alpha-catalytic subunit |
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| Type: | Enzyme |
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| Mol. Mass.: | 40766.33 |
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| Organism: | Oryctolagus cuniculus (Rabbit) |
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| Description: | Q95J97 |
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| Residue: | 351 |
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| Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAQLDQFERIKTLGTGSFGRVML
SKHKETGNHYAMKILDKQKVVKLKQIEHTLNVKRILQAVNFPFLVKLEFSFKENSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQQTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAADYPPFF
ADQPIQIYEKIVYGKVRFPSHFSSDLKDLLRNLQQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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| BDBM6760 |
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| n/a |
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| Name | BDBM6760 |
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| Synonyms: | (+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaene-16-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C27H21N3O5 |
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| Mol. Mass. | 467.4727 |
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| SMILES | COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| |
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| Structure | 
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