Reaction Details |
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Target | Phosphodiesterase |
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Ligand | BDBM50059023 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_156454 (CHEMBL764832) |
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IC50 | 25000±n/a nM |
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Citation | Ahn, HS; Bercovici, A; Boykow, G; Bronnenkant, A; Chackalamannil, S; Chow, J; Cleven, R; Cook, J; Czarniecki, M; Domalski, C; Fawzi, A; Green, M; Gündes, A; Ho, G; Laudicina, M; Lindo, N; Ma, K; Manna, M; McKittrick, B; Mirzai, B; Nechuta, T; Neustadt, B; Puchalski, C; Pula, K; Zhang, H Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity. J Med Chem40:2196-210 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Phosphodiesterase |
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Name: | Phosphodiesterase |
Synonyms: | Heart phosphodiesterase | Phosphodiesterase 3B |
Type: | PROTEIN |
Mol. Mass.: | 124301.20 |
Organism: | Bos taurus |
Description: | ChEMBL_156453 |
Residue: | 1115 |
Sequence: | MRRDERDAKAMRSPPPPDGAASPPESVRNGYVKGCVSPLRQDPPRGFFFHLCRFCNVELL
LPPPASPQQPRRGSPFSRARLLLGALAAFVLALLLGSGPESWAAGAARLRTLLSVCSQSL
SPLFSIACAFFFLTCFLTRTKRGAGPGRSGGGSWWLLALPACCYLGDFLVGQWESWSRGD
GDARAPVPHTPPAVAGRWFLVLSCVGLLTLAQPGRLRHSIVVLLFSSFVWWVSFTSLGAL
PPALRPLLSCLVGGVGCLLALGLDHFFQIREAPQQPQLSSTAEEKVPVIRPRRRSSCVSF
GETSGGYYGSCKMFRRPSLPCISREQMILWDWDLKQWYKPHYQISGGGSGVDLSVLNEAR
NMVSDLLVDPTLPPQVIASLRSISSLMGAFSGSCRPKMNPLTPFPGFYPCSEIEDPAEKG
DRKLHKGLNSRNSLPTPHLRRSSGTSGLPPIDQTSPRWERNNGKRPHQEFGILSQGCYLN
GPFSSNLLTVPKQRSSSVSLTHHVGLRRAGGLPSMNSPSHGPVSAGSPANRSPIEFPDTA
EFLTKPPVILHKSLSSTPNSPDFYQQLRNSDSNLCNSCGHQILKYDSASEPESGTDCHRE
KSGGEDNTVFSKASFNLTEAQQEVETENRDGRKLLWEGENHLKAAAQNEEQPNIEQEASQ
DLILIEDYDSLIENMSNWNFQIFELVEKMGEKSGRILSQVVYTLFQDTGLLEIFKIPTLQ
FMNYFHALENGYRDIPYHNRIHATDVLHAVWYLTTRPIPGLQEIHSDHGAGNETAINPER
IAYISSRSCSIPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVL
YNDRSVLENHHAASAWTLYLSRPEYNFLLNLDNVEFKRFRFLVIEAILATDLKKHFDFLA
EFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPTKVRDLHLKWTEGIVNEFYEQG
DEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWIESEEDDDTE
SCYEEEDAEELDTEDEEIEDNLNSKPQRRKGRRQIFCQLMHHLTENHKIWKEIIEEEEKC
KADGNKLQMENSSLPQGDEIQVIEEADEEEERQLE
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BDBM50059023 |
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n/a |
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Name | BDBM50059023 |
Synonyms: | 5'-Methyl-2'-(phenylmethyl)spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4(5'H)-one | CHEMBL72812 |
Type | Small organic molecule |
Emp. Form. | C19H21N5O |
Mol. Mass. | 335.4029 |
SMILES | CN1C2=NC3(CCCC3)CN2c2nc(Cc3ccccc3)[nH]c2C1=O |t:2| |
Structure |
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