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TargetPhosphodiesterase
LigandBDBM50059023
Substrate/Competitorn/a
Meas. Tech.ChEMBL_156454 (CHEMBL764832)
IC50 25000±n/a nM
Citation Ahn, HSBercovici, ABoykow, GBronnenkant, AChackalamannil, SChow, JCleven, RCook, JCzarniecki, MDomalski, CFawzi, AGreen, MGündes, AHo, GLaudicina, MLindo, NMa, KManna, MMcKittrick, BMirzai, BNechuta, TNeustadt, BPuchalski, CPula, KZhang, H Potent tetracyclic guanine inhibitors of PDE1 and PDE5 cyclic guanosine monophosphate phosphodiesterases with oral antihypertensive activity. J Med Chem40:2196-210 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Phosphodiesterase
Name:Phosphodiesterase
Synonyms:Heart phosphodiesterase | Phosphodiesterase 3B
Type:PROTEIN
Mol. Mass.:124301.20
Organism:Bos taurus
Description:ChEMBL_156453
Residue:1115
Sequence:
MRRDERDAKAMRSPPPPDGAASPPESVRNGYVKGCVSPLRQDPPRGFFFHLCRFCNVELL
LPPPASPQQPRRGSPFSRARLLLGALAAFVLALLLGSGPESWAAGAARLRTLLSVCSQSL
SPLFSIACAFFFLTCFLTRTKRGAGPGRSGGGSWWLLALPACCYLGDFLVGQWESWSRGD
GDARAPVPHTPPAVAGRWFLVLSCVGLLTLAQPGRLRHSIVVLLFSSFVWWVSFTSLGAL
PPALRPLLSCLVGGVGCLLALGLDHFFQIREAPQQPQLSSTAEEKVPVIRPRRRSSCVSF
GETSGGYYGSCKMFRRPSLPCISREQMILWDWDLKQWYKPHYQISGGGSGVDLSVLNEAR
NMVSDLLVDPTLPPQVIASLRSISSLMGAFSGSCRPKMNPLTPFPGFYPCSEIEDPAEKG
DRKLHKGLNSRNSLPTPHLRRSSGTSGLPPIDQTSPRWERNNGKRPHQEFGILSQGCYLN
GPFSSNLLTVPKQRSSSVSLTHHVGLRRAGGLPSMNSPSHGPVSAGSPANRSPIEFPDTA
EFLTKPPVILHKSLSSTPNSPDFYQQLRNSDSNLCNSCGHQILKYDSASEPESGTDCHRE
KSGGEDNTVFSKASFNLTEAQQEVETENRDGRKLLWEGENHLKAAAQNEEQPNIEQEASQ
DLILIEDYDSLIENMSNWNFQIFELVEKMGEKSGRILSQVVYTLFQDTGLLEIFKIPTLQ
FMNYFHALENGYRDIPYHNRIHATDVLHAVWYLTTRPIPGLQEIHSDHGAGNETAINPER
IAYISSRSCSIPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVL
YNDRSVLENHHAASAWTLYLSRPEYNFLLNLDNVEFKRFRFLVIEAILATDLKKHFDFLA
EFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPTKVRDLHLKWTEGIVNEFYEQG
DEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWIESEEDDDTE
SCYEEEDAEELDTEDEEIEDNLNSKPQRRKGRRQIFCQLMHHLTENHKIWKEIIEEEEKC
KADGNKLQMENSSLPQGDEIQVIEEADEEEERQLE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50059023
n/a
NameBDBM50059023
Synonyms:5'-Methyl-2'-(phenylmethyl)spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4(5'H)-one | CHEMBL72812
TypeSmall organic molecule
Emp. Form.C19H21N5O
Mol. Mass.335.4029
SMILESCN1C2=NC3(CCCC3)CN2c2nc(Cc3ccccc3)[nH]c2C1=O |t:2|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: