| Reaction Details |
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 | Report a problem with these data |
| Target | Folate receptor alpha |
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| Ligand | BDBM50059331 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_68374 (CHEMBL678783) |
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| Kd | 0.95±n/a nM |
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| Citation |  Varney, MD; Palmer, CL; Romines, WH; Boritzki, T; Margosiak, SA; Almassy, R; Janson, CA; Bartlett, C; Howland, EJ; Ferre, R Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition. J Med Chem40:2502-24 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Folate receptor alpha |
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| Name: | Folate receptor alpha |
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| Synonyms: | Adult folate-binding protein | FBP | FOLR | FOLR1 | FOLR1_HUMAN | FR-alpha | Folate receptor 1 | Folate receptor, adult | KB cells FBP | Ovarian tumor-associated antigen MOv18 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 29827.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469596 |
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| Residue: | 257 |
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| Sequence: | MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPW
RKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQV
DQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHF
YFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWA
AWPFLLSLALMLLWLLS
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| BDBM50059331 |
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| n/a |
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| Name | BDBM50059331 |
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| Synonyms: | (R)-2-({5-[2-(2-Amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimido[5,4-b][1,4]thiazin-6-yl)-ethyl]-4-methyl-thiophene-2-carbonyl}-amino)-pentanedioic acid | CHEMBL82261 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N5O6S2 |
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| Mol. Mass. | 481.546 |
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| SMILES | Cc1cc(sc1CCC1CNc2nc(N)[nH]c(=O)c2S1)C(=O)N[C@H](CCC(O)=O)C(O)=O |
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| Structure | 
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