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TargetGTPase HRas
LigandBDBM50060139
Substrate/Competitorn/a
Meas. Tech.ChEMBL_76422
IC50 88.0±n/a nM
Citation McNamara DJDobrusin ELeonard DMShuler KRKaltenbronn JSQuin JBur SThomas CEDoherty AMScholten JDZimmerman KKGibbs BSGowan RCLatash MPLeopold WRPrzybranowski SASebolt-Leopold JS C-terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of Ras farnesyltransferase, cellular activity, and anticancer activity in mice. J Med Chem 40:3319-22 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
GTPase HRas
Name:GTPase HRas
Synonyms:GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras
Type:Other Protein Type
Mol. Mass.:21293.37
Organism:Homo sapiens (Human)
Description:P01112
Residue:189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50060139
n/a
NameBDBM50060139
Synonyms:CHEMBL326352 | [(S)-1-((4-Benzyloxy-benzyl)-{[(1-phenyl-cyclobutylmethyl)-carbamoyl]-methyl}-carbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester
TypeSmall organic molecule
Emp. Form.C41H43N5O5
Mol. Mass.685.8106
SMILESO=C(CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)NCC1(CCC1)c1ccccc1
Structure
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