Reaction Details |
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Target | GTPase HRas |
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Ligand | BDBM50060143 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_76422 (CHEMBL685869) |
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IC50 | 6300±n/a nM |
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Citation | McNamara, DJ; Dobrusin, E; Leonard, DM; Shuler, KR; Kaltenbronn, JS; Quin, J; Bur, S; Thomas, CE; Doherty, AM; Scholten, JD; Zimmerman, KK; Gibbs, BS; Gowan, RC; Latash, MP; Leopold, WR; Przybranowski, SA; Sebolt-Leopold, JS C-terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of Ras farnesyltransferase, cellular activity, and anticancer activity in mice. J Med Chem40:3319-22 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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GTPase HRas |
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Name: | GTPase HRas |
Synonyms: | GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras |
Type: | Other Protein Type |
Mol. Mass.: | 21293.37 |
Organism: | Homo sapiens (Human) |
Description: | P01112 |
Residue: | 189 |
Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
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BDBM50060143 |
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n/a |
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Name | BDBM50060143 |
Synonyms: | CHEMBL324345 | [(S)-1-{(4-Benzyloxy-benzyl)-[((S)-1-methyl-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester |
Type | Small organic molecule |
Emp. Form. | C39H41N5O5 |
Mol. Mass. | 659.7733 |
SMILES | C[C@@H](Cc1ccccc1)NC(=O)CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1 |
Structure |
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