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TargetGTPase HRas
LigandBDBM50060146
Substrate/Competitorn/a
Meas. Tech.ChEMBL_76422 (CHEMBL685869)
IC50 180±n/a nM
Citation McNamara, DJDobrusin, ELeonard, DMShuler, KRKaltenbronn, JSQuin, JBur, SThomas, CEDoherty, AMScholten, JDZimmerman, KKGibbs, BSGowan, RCLatash, MPLeopold, WRPrzybranowski, SASebolt-Leopold, JS C-terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of Ras farnesyltransferase, cellular activity, and anticancer activity in mice. J Med Chem40:3319-22 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
GTPase HRas
Name:GTPase HRas
Synonyms:GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras
Type:Other Protein Type
Mol. Mass.:21293.37
Organism:Homo sapiens (Human)
Description:P01112
Residue:189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
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  Blast E-value cutoff:
BDBM50060146
n/a
NameBDBM50060146
Synonyms:CHEMBL407445 | [(S)-1-((4-Benzyloxy-benzyl)-{[(1-phenyl-cyclopropylmethyl)-carbamoyl]-methyl}-carbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester
TypeSmall organic molecule
Emp. Form.C40H41N5O5
Mol. Mass.671.784
SMILESO=C(CN(Cc1ccc(OCc2ccccc2)cc1)C(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)NCC1(CC1)c1ccccc1
Structure
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