Ki Summary

Reaction Details

Report a problem with these data

Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50060321

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_48609 (CHEMBL659590)

342±n/a nM

Citation

Martín-Martínez, M; Bartolomé-Nebreda, JM; Gómez-Monterrey, I; González-Muñiz, R; García-López, MT; Ballaz, S; Barber, A; Fortuño, A; Del Río, J; Herranz, R Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists. J Med Chem40:3402-7 (1997) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

48980.43

Organism:

RAT

Description:

Cholecystokinin A CCKBR RAT::P30553

Residue:

452

Sequence:

MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWL
LSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGL
ISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCV
QLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTW
RAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRA
RPQPLPDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50060321

n/a

Name

BDBM50060321

Synonyms:

1H-Indole-2-carboxylic acid ((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide | 1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide | CCK antagonist synthetic 19 | CHEMBL419764

Type

Small organic molecule

Emp. Form.

C25H20N4O2

Mol. Mass.

408.4519

SMILES

CN1c2ccccc2C(=N[C@@H](NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1 |c:9|

Structure