| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50279766 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63999 (CHEMBL673108) |
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| Ki | 200±n/a nM |
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| Citation |  Regan, J; McGarry, D; Bruno, J; Green, D; Newman, J; Hsu, CY; Kline, J; Barton, J; Travis, J; Choi, YM; Volz, F; Pauls, H; Harrison, R; Zilberstein, A; Ben-Sasson, SA; Chang, M Anionic- and lipophilic-mediated surface binding inhibitors of human leukocyte elastase. J Med Chem40:3408-22 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50279766 |
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| n/a |
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| Name | BDBM50279766 |
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| Synonyms: | CHEMBL213783 | {2-{5-Benzyloxy-4-[4-(5-benzyloxy-4-hydroxymethyl-2-methoxy-benzyl)-5-carboxymethoxy-2-methoxy-benzyl]-2-methoxy-benzyl}-5-[2-benzyloxy-4-(2-carboxymethoxy-5-hydroxy-benzyl)-5-methoxy-benzyl]-4-methoxy-phenoxy}-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C74H72O19 |
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| Mol. Mass. | 1265.3521 |
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| SMILES | COc1cc(CO)c(OCc2ccccc2)cc1Cc1cc(OC)c(Cc2cc(OC)c(Cc3cc(OC)c(Cc4cc(OC)c(Cc5cc(O)ccc5OCC(O)=O)cc4OCc4ccccc4)cc3OCC(O)=O)cc2OCc2ccccc2)cc1OCC(O)=O |
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| Structure | 
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