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TargetNeutrophil elastase
LigandBDBM50279770
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63999 (CHEMBL673108)
Ki 120±n/a nM
Citation Regan, JMcGarry, DBruno, JGreen, DNewman, JHsu, CYKline, JBarton, JTravis, JChoi, YMVolz, FPauls, HHarrison, RZilberstein, ABen-Sasson, SAChang, M Anionic- and lipophilic-mediated surface binding inhibitors of human leukocyte elastase. J Med Chem40:3408-22 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50279770
n/a
NameBDBM50279770
Synonyms:2-{4-benzyloxy-5-[5-benzyloxy-4-(5-benzyloxy-4-{5-benzyloxy-4-[5-benzyloxy-2-carboxymethoxy-4-(2-carboxymethoxy-5-hydroxybenzyl)benzyl]-2-carboxymethoxybenzyl}-2-carboxymethoxybenzyl)-2-carboxymethoxybenzyl]-2-hydroxymethylphenoxy}acetic acid.H2O | CHEMBL267968
TypeSmall organic molecule
Emp. Form.C89H80O25
Mol. Mass.1549.5725
SMILESOCc1cc(OCc2ccccc2)c(Cc2cc(OCc3ccccc3)c(Cc3cc(OCc4ccccc4)c(Cc4cc(OCc5ccccc5)c(Cc5cc(OCc6ccccc6)c(Cc6cc(O)ccc6OCC(O)=O)cc5OCC(O)=O)cc4OCC(O)=O)cc3OCC(O)=O)cc2OCC(O)=O)cc1OCC(O)=O
Structure
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