| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transporter |
|---|
| Ligand | BDBM50060485 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_192826 (CHEMBL797692) |
|---|
| IC50 | 3000±n/a nM |
|---|
| Citation |  McKenna, MT; Proctor, GR; Young, LC; Harvey, AL Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. J Med Chem40:3516-23 (1997) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transporter |
|---|
| Name: | Transporter |
|---|
| Synonyms: | Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 66787.87 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1463061 |
|---|
| Residue: | 597 |
|---|
| Sequence: | MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLF
YMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLN
LPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDI
GLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNG
INAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTIN
CVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFL
MLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLT
LLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLL
FVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAY
GITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI
|
|
|
|---|
| BDBM50060485 |
|---|
| n/a |
|---|
| Name | BDBM50060485 |
|---|
| Synonyms: | 6,7-Dihydro-5H-benzo[2,3]azepino[4,5-b]quinolin-8-ylamine | CHEMBL115697 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H15N3 |
|---|
| Mol. Mass. | 261.3211 |
|---|
| SMILES | Nc1c2CCNc3ccccc3-c2nc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
