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TargetSerine protease 1
LigandBDBM50060739
Substrate/Competitorn/a
Meas. Tech.ChEMBL_212515 (CHEMBL817580)
Ki 430±n/a nM
Citation Feng, DMGardell, SJLewis, SDBock, MGChen, ZFreidinger, RMNaylor-Olsen, AMRamjit, HGWoltmann, RBaskin, EPLynch, JJLucas, RShafer, JADancheck, KBChen, IWMao, SSKrueger, JAHare, TRMulichak, AMVacca, JP Discovery of a novel, selective, and orally bioavailable class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position. J Med Chem40:3726-33 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine protease 1
Name:Serine protease 1
Synonyms:Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:Enzyme
Mol. Mass.:25790.52
Organism:Bos taurus (bovine)
Description:P00760
Residue:246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVS
AAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLN
SRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQIT
SNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIK
QTIASN
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  Blast E-value cutoff:
BDBM50060739
n/a
NameBDBM50060739
Synonyms:(S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethanesulfonylamino-propionyl]-pyrrolidine-2-carboxylic acid (6-amino-pyridin-3-ylmethyl)-amide | CHEMBL121982
TypeSmall organic molecule
Emp. Form.C27H29Cl2N5O4S
Mol. Mass.590.521
SMILESNc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(Cl)c(Cl)c2)NS(=O)(=O)Cc2ccccc2)cn1
Structure
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