| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Chymotrypsin-like elastase family member 2A |
|---|
| Ligand | BDBM50058391 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_152313 (CHEMBL756766) |
|---|
| Ki | 200±n/a nM |
|---|
| Citation |  Veale, CA; Bernstein, PR; Bohnert, CM; Brown, FJ; Bryant, C; Damewood, JR; Earley, R; Feeney, SW; Edwards, PD; Gomes, B; Hulsizer, JM; Kosmider, BJ; Krell, RD; Moore, G; Salcedo, TW; Shaw, A; Silberstein, DS; Steelman, GB; Stein, M; Strimpler, A; Thomas, RM; Vacek, EP; Williams, JC; Wolanin, DJ; Woolson, S Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase. J Med Chem40:3173-81 (1997) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Chymotrypsin-like elastase family member 2A |
|---|
| Name: | Chymotrypsin-like elastase family member 2A |
|---|
| Synonyms: | CEL2A_PIG | CELA2A | ELA2 | ELA2A | Elastase 2A | Elastase-2 | Elastase-2A | Pancreatic elastase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 28705.23 |
|---|
| Organism: | Sus scrofa |
|---|
| Description: | ChEMBL_156951 |
|---|
| Residue: | 269 |
|---|
| Sequence: | MIRALLLSTLVAGALSCGLPANLPQLPRVVGGEDARPNSWPWQVSLQYDSSGQWRHTCGG
TLVDQSWVLTAAHCISSSRTYRVVLGRHSLSTNEPGSLAVKVSKLVVHQDWNSNQLSNGN
DIALLKLASPVSLTDKIQLGCLPAAGTILPNNYVCYVTGWGRLQTNGASPDILQQGQLLV
VDYATCSKPGWWGSTVKTNMICAGGDGIISSCNGDSGGPLNCQGANGQWQVHGIVSFGSS
LGCNYYHKPSVFTRVSNYIDWINSVIANN
|
|
|
|---|
| BDBM50058391 |
|---|
| n/a |
|---|
| Name | BDBM50058391 |
|---|
| Synonyms: | (S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid ((S)-3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide | CHEMBL55210 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H32F3N3O5 |
|---|
| Mol. Mass. | 499.5232 |
|---|
| SMILES | COc1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
