Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetNeutrophil elastase
LigandBDBM50061033
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63839 (CHEMBL674889)
Ki 8±n/a nM
Citation Veale, CABernstein, PRBohnert, CMBrown, FJBryant, CDamewood, JREarley, RFeeney, SWEdwards, PDGomes, BHulsizer, JMKosmider, BJKrell, RDMoore, GSalcedo, TWShaw, ASilberstein, DSSteelman, GBStein, MStrimpler, AThomas, RMVacek, EPWilliams, JCWolanin, DJWoolson, S Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase. J Med Chem40:3173-81 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50061033
n/a
NameBDBM50061033
Synonyms:(S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid [(S)-1-(5-acetylamino-benzooxazole-2-carbonyl)-2-methyl-propyl]-amide | CHEMBL278682
TypeSmall organic molecule
Emp. Form.C32H39N5O7
Mol. Mass.605.6814
SMILESCOc1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)c1nc2cc(NC(C)=O)ccc2o1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: