Ki Summary

Reaction Details

Report a problem with these data

Target

Mast cell carboxypeptidase A

Ligand

BDBM50058391

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_45632 (CHEMBL655442)

17000±n/a nM

Citation

Veale, CA; Bernstein, PR; Bohnert, CM; Brown, FJ; Bryant, C; Damewood, JR; Earley, R; Feeney, SW; Edwards, PD; Gomes, B; Hulsizer, JM; Kosmider, BJ; Krell, RD; Moore, G; Salcedo, TW; Shaw, A; Silberstein, DS; Steelman, GB; Stein, M; Strimpler, A; Thomas, RM; Vacek, EP; Williams, JC; Wolanin, DJ; Woolson, S Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase. J Med Chem40:3173-81 (1997) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mast cell carboxypeptidase A

Name:

Mast cell carboxypeptidase A

Synonyms:

CBPA3_HUMAN | CPA3 | Carboxypeptidase A3 | MC-CPA

Type:

PROTEIN

Mol. Mass.:

48684.88

Organism:

Homo sapiens (Human)

Description:

ChEMBL_45634

Residue:

417

Sequence:

MRLILPVGLIATTLAIAPVRFDREKVFRVKPQDEKQADIIKDLAKTNELDFWYPGATHHV
AANMMVDFRVSEKESQAIQSALDQNKMHYEILIHDLQEEIEKQFDVKEDIPGRHSYAKYN
NWEKIVAWTEKMMDKYPEMVSRIKIGSTVEDNPLYVLKIGEKNERRKAIFTDCGIHAREW
VSPAFCQWFVYQATKTYGRNKIMTKLLDRMNFYILPVFNVDGYIWSWTKNRMWRKNRSKN
QNSKCIGTDLNRNFNASWNSIPNTNDPCADNYRGSAPESEKETKAVTNFIRSHLNEIKVY
ITFHSYSQMLLFPYGYTSKLPPNHEDLAKVAKIGTDVLSTRYETRYIYGPIESTIYPISG
SSLDWAYDLGIKHTFAFELRDKGKFGFLLPESRIKPTCRETMLAVKFIAKYILKHTS

BDBM50058391

n/a

Name

BDBM50058391

Synonyms:

(S)-1-[(S)-2-(4-Methoxy-benzoylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid ((S)-3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide | CHEMBL55210

Type

Small organic molecule

Emp. Form.

C24H32F3N3O5

Mol. Mass.

499.5232

SMILES

COc1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F

Structure