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TargetNeutrophil elastase
LigandBDBM50061044
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63839 (CHEMBL674889)
Ki 0.64±n/a nM
Citation Veale, CABernstein, PRBohnert, CMBrown, FJBryant, CDamewood, JREarley, RFeeney, SWEdwards, PDGomes, BHulsizer, JMKosmider, BJKrell, RDMoore, GSalcedo, TWShaw, ASilberstein, DSSteelman, GBStein, MStrimpler, AThomas, RMVacek, EPWilliams, JCWolanin, DJWoolson, S Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase. J Med Chem40:3173-81 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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  Blast E-value cutoff:
BDBM50061044
n/a
NameBDBM50061044
Synonyms:2-((S)-3-Methyl-2-{[(S)-1-((S)-3-methyl-2-phenoxycarbonylamino-butyryl)-pyrrolidine-2-carbonyl]-amino}-butyryl)-benzooxazole-5-carboxylic acid methyl ester | CHEMBL108622
TypeSmall organic molecule
Emp. Form.C31H36N4O8
Mol. Mass.592.6395
SMILESCOC(=O)c1ccc2oc(nc2c1)C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)Oc1ccccc1)C(C)C)C(C)C
Structure
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