| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin receptor type B |
|---|
| Ligand | BDBM50050964 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_63520 (CHEMBL677268) |
|---|
| IC50 | 4.4±n/a nM |
|---|
| Citation |  Jae, HS; Winn, M; Dixon, DB; Marsh, KC; Nguyen, B; Opgenorth, TJ; von Geldern, TW Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonists. J Med Chem40:3217-27 (1997) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin receptor type B |
|---|
| Name: | Endothelin receptor type B |
|---|
| Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 49664.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
|---|
| Residue: | 442 |
|---|
| Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
|
|
|
|---|
| BDBM50050964 |
|---|
| n/a |
|---|
| Name | BDBM50050964 |
|---|
| Synonyms: | 4-[1-Benzo[1,3]dioxol-5-yl-2-(4-isopropyl-benzenesulfonylamino)-2-oxo-ethoxy]-3-propyl-benzoic acid | CHEMBL8978 | L-754142 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H29NO8S |
|---|
| Mol. Mass. | 539.597 |
|---|
| SMILES | CCCc1cc(ccc1OC(C(=O)NS(=O)(=O)c1ccc(cc1)C(C)C)c1ccc2OCOc2c1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
