| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin receptor type B |
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| Ligand | BDBM50061086 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63872 (CHEMBL671334) |
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| IC50 | 0.2±n/a nM |
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| Citation |  Jae, HS; Winn, M; Dixon, DB; Marsh, KC; Nguyen, B; Opgenorth, TJ; von Geldern, TW Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonists. J Med Chem40:3217-27 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin receptor type B |
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| Name: | Endothelin receptor type B |
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| Synonyms: | EDNRB | EDNRB_PIG | Endothelin receptor ET-B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49616.89 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_63872 |
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| Residue: | 443 |
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| Sequence: | MQPLRSLCGRALVALIFACGVAGVQSEERGFPPAGATPPALRTGEIVAPPTKTFWPRGSN
ASLPRSSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGN
STLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPF
IQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEALG
FDMITTDYKGNRLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCE
MLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQNDSNRCE
LLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQS
CLKFKANDHGYDNFRSSNKYSSS
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| BDBM50061086 |
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| n/a |
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| Name | BDBM50061086 |
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| Synonyms: | (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(3-chloro-propane-1-sulfonyl)-propyl-amino]-ethyl}-2-(3-fluoro-4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid | CHEMBL325581 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H34ClFN2O7S |
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| Mol. Mass. | 585.084 |
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| SMILES | CCCN(CCN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)c(F)c1)C(O)=O)c1ccc2OCOc2c1)S(=O)(=O)CCCCl |
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| Structure | 
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