| Reaction Details |
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 | Report a problem with these data |
| Target | Aromatase |
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| Ligand | BDBM50061154 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_50543 (CHEMBL660322) |
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| Ki | 47.6±n/a nM |
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| Citation |  Akkani, A; Paterlini, G; Gleason, WB; Ojala, WH; Abul-Hajj, YJ 6 beta-Propynyl-substituted steroids: mechanism-based enzyme-activated irreversible inhibitors of aromatase. J Med Chem40:3263-70 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aromatase |
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| Name: | Aromatase |
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| Synonyms: | ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM |
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| Type: | Enzyme |
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| Mol. Mass.: | 57888.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11511 |
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| Residue: | 503 |
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| Sequence: | MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
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| BDBM50061154 |
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| n/a |
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| Name | BDBM50061154 |
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| Synonyms: | (S)-13-Methyl-6-prop-2-ynyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-2H-cyclopenta[a]phenanthrene-3,17-dione | CHEMBL109211 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26O2 |
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| Mol. Mass. | 310.4299 |
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| SMILES | CC12CCC3C(C[C@@H](CC#C)C4=CC(=O)CCC34)C1CCC2=O |t:11| |
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| Structure | 
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