Reaction Details | |||
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Target | Reverse transcriptase/RNaseH | ||
Ligand | BDBM17666 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_79624 (CHEMBL693710) | ||
EC50 | >20000±n/a nM | ||
Citation | Roth, T; Morningstar, ML; Boyer, PL; Hughes, SH; Buckheit, RW; Michejda, CJ Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles. J Med Chem40:4199-207 (1998) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Reverse transcriptase/RNaseH | |||
Name: | Reverse transcriptase/RNaseH | ||
Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH | ||
Type: | PROTEIN | ||
Mol. Mass.: | 65229.15 | ||
Organism: | Human immunodeficiency virus 1 | ||
Description: | ChEMBL_1473730 | ||
Residue: | 566 | ||
Sequence: |
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BDBM17666 | |||
n/a | |||
Name | BDBM17666 | ||
Synonyms: | 2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)methyl]-1H-1,3-benzodiazole | CHEMBL58581 | benzimidazole analogue, 2 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H12F4N2 | ||
Mol. Mass. | 356.3163 | ||
SMILES | Fc1cccc(F)c1Cn1c(nc2ccccc12)-c1c(F)cccc1F |(-3.45,3.05,;-4.22,1.72,;-5.76,1.72,;-6.53,.39,;-5.76,-.95,;-4.22,-.95,;-3.45,-2.28,;-3.45,.39,;-1.91,.34,;-1.14,1.68,;.39,1.52,;1.02,2.92,;-.12,3.95,;-.12,5.5,;-1.46,6.27,;-2.79,5.5,;-2.79,3.95,;-1.46,3.18,;1.16,.18,;2.7,.18,;3.47,1.52,;3.47,-1.15,;2.7,-2.48,;1.16,-2.48,;.39,-1.15,;-1.15,-1.15,)| | ||
Structure |