| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-gamma |
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| Ligand | BDBM50061619 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_196643 (CHEMBL800756) |
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| Ki | 1000±n/a nM |
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| Citation |  Umemiya, H; Fukasawa, H; Ebisawa, M; Eyrolles, L; Kawachi, E; Eisenmann, G; Gronemeyer, H; Hashimoto, Y; Shudo, K; Kagechika, H Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J Med Chem40:4222-34 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-gamma |
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| Name: | Retinoic acid receptor RXR-gamma |
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| Synonyms: | NR2B3 | Nuclear receptor subfamily 2 group B member 3 | RXRG | RXRG_HUMAN | Retinoic acid receptor RXR-gamma | Retinoid X receptor gamma | Retinoid X receptor gamma/retinoic acid receptor alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50878.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_197216 |
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| Residue: | 463 |
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| Sequence: | MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVG
TPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPG
IGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKD
CLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERIL
EAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVI
LLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKD
MQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLL
LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
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| BDBM50061619 |
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| n/a |
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| Name | BDBM50061619 |
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| Synonyms: | 4-(7,7,10,10-Tetramethyl-7,8,9,10-tetrahydro-5H-13-aza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl)-benzoic acid | CHEMBL134834 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H29NO2 |
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| Mol. Mass. | 423.5461 |
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| SMILES | CC1(C)CCC(C)(C)c2cc3c(Cc4ccccc4N=C3c3ccc(cc3)C(O)=O)cc12 |c:20| |
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| Structure | 
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