| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
|---|
| Ligand | BDBM50004141 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_197283 (CHEMBL804270) |
|---|
| EC50 | 6.9±n/a nM |
|---|
| Citation |  Kireev, DB; Chrétien, JR; Grierson, DS; Monneret, C A 3D QSAR study of a series of HEPT analogues: the influence of conformational mobility on HIV-1 reverse transcriptase inhibition. J Med Chem40:4257-64 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Reverse transcriptase/RNaseH |
|---|
| Name: | Reverse transcriptase/RNaseH |
|---|
| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 65229.15 |
|---|
| Organism: | Human immunodeficiency virus 1 |
|---|
| Description: | ChEMBL_1473730 |
|---|
| Residue: | 566 |
|---|
| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
|
|
|
|---|
| BDBM50004141 |
|---|
| n/a |
|---|
| Name | BDBM50004141 |
|---|
| Synonyms: | 1-Benzyloxymethyl-6-(3,5-dimethyl-phenylsulfanyl)-5-ethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one | CHEMBL135497 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H24N2O2S2 |
|---|
| Mol. Mass. | 412.568 |
|---|
| SMILES | CCc1c(Sc2cc(C)cc(C)c2)n(COCc2ccccc2)c(=S)[nH]c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
