| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine 3-monooxygenase |
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| Ligand | BDBM50061916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_91740 (CHEMBL702202) |
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| IC50 | 37±n/a nM |
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| Citation |  Röver, S; Cesura, AM; Huguenin, P; Kettler, R; Szente, A Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem40:4378-85 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine 3-monooxygenase |
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| Name: | Kynurenine 3-monooxygenase |
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| Synonyms: | KMO_RAT | Kmo |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54371.88 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1487468 |
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| Residue: | 478 |
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| Sequence: | MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSY
RGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLT
AVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKK
PRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMS
FEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCV
LMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLS
MYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKK
VINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH
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| BDBM50061916 |
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| n/a |
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| Name | BDBM50061916 |
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| Synonyms: | 3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzenesulfonamide | CHEMBL134915 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15N3O6S2 |
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| Mol. Mass. | 421.448 |
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| SMILES | COc1ccc(cc1OC)S(=O)(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O |
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| Structure | 
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