Ki Summary

Reaction Details

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Target

Platelet-activating factor receptor

Ligand

BDBM50062071

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_158347 (CHEMBL768491)

2.4±n/a nM

Citation

Curtin, ML; Davidsen, SK; Heyman, HR; Garland, RB; Sheppard, GS; Florjancic, AS; Xu, L; Carrera, GM; Steinman, DH; Trautmann, JA; Albert, DH; Magoc, TJ; Tapang, P; Rhein, DA; Conway, RG; Luo, G; Denissen, JF; Marsh, KC; Morgan, DW; Summers, JB Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists. J Med Chem41:74-95 (1998) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Platelet-activating factor receptor

Name:

Platelet-activating factor receptor

Synonyms:

PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor

Type:

Protein

Mol. Mass.:

39005.63

Organism:

Cavia porcellus

Description:

n/a

Residue:

342

Sequence:

MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLT
VADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVK
YPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKG
SKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAV
FVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN

BDBM50062071

n/a

Name

BDBM50062071

Synonyms:

1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-cyclohexanecarbonyl]-1H-indole-4-carboxylic acid methyl ester | CHEMBL368185

Type

Small organic molecule

Emp. Form.

C28H31N5O4

Mol. Mass.

501.5768

SMILES

COC(=O)c1cccc2n(cc(C(=O)C3CCC(Cn4c(C)nc5cnccc45)CC3)c12)C(=O)N(C)C |(5.2,-3.63,;5.2,-5.17,;3.88,-5.94,;2.54,-5.18,;3.88,-7.46,;2.55,-8.26,;2.55,-9.82,;3.88,-10.59,;5.23,-9.82,;6.71,-10.3,;7.63,-9.02,;6.71,-7.76,;7.18,-6.29,;6.41,-4.95,;8.71,-6.13,;9.75,-5.41,;11.56,-5.59,;11.95,-4.1,;12.85,-2.85,;14.38,-2.69,;15.47,-3.77,;15.24,-5.3,;16.83,-3.06,;16.57,-1.55,;17.53,-.36,;16.98,1.06,;15.46,1.3,;14.52,.11,;15.06,-1.31,;10.83,-4.82,;9.11,-4.64,;5.23,-8.26,;7.2,-11.75,;6.42,-13.08,;8.72,-11.91,;9.35,-13.31,;9.63,-10.67,)|

Structure