Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPlatelet activating factor receptor
LigandBDBM50062071
Substrate/Competitorn/a
Meas. Tech.ChEMBL_158347
Ki 2.4±n/a nM
Citation Curtin MLDavidsen SKHeyman HRGarland RBSheppard GSFlorjancic ASXu LCarrera GMSteinman DHTrautmann JAAlbert DHMagoc TJTapang PRhein DAConway RGLuo GDenissen JFMarsh KCMorgan DWSummers JB Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists. J Med Chem 41:74-95 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Platelet activating factor receptor
Name:Platelet activating factor receptor
Synonyms:PAF-R | Platelet-activating factor receptor
Type:Protein
Mol. Mass.:39005.63
Organism:Cavia porcellus
Description:n/a
Residue:342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLT
VADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVK
YPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKG
SKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAV
FVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50062071
n/a
NameBDBM50062071
Synonyms:1-Dimethylcarbamoyl-3-[4-(2-methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-cyclohexanecarbonyl]-1H-indole-4-carboxylic acid methyl ester | CHEMBL368185
TypeSmall organic molecule
Emp. Form.C28H31N5O4
Mol. Mass.501.5768
SMILESCOC(=O)c1cccc2n(cc(C(=O)C3CCC(Cn4c(C)nc5cnccc45)CC3)c12)C(=O)N(C)C |(5.2,-3.63,;5.2,-5.17,;3.88,-5.94,;2.54,-5.18,;3.88,-7.46,;2.55,-8.26,;2.55,-9.82,;3.88,-10.59,;5.23,-9.82,;6.71,-10.3,;7.63,-9.02,;6.71,-7.76,;7.18,-6.29,;6.41,-4.95,;8.71,-6.13,;9.75,-5.41,;11.56,-5.59,;11.95,-4.1,;12.85,-2.85,;14.38,-2.69,;15.47,-3.77,;15.24,-5.3,;16.83,-3.06,;16.57,-1.55,;17.53,-.36,;16.98,1.06,;15.46,1.3,;14.52,.11,;15.06,-1.31,;10.83,-4.82,;9.11,-4.64,;5.23,-8.26,;7.2,-11.75,;6.42,-13.08,;8.72,-11.91,;9.35,-13.31,;9.63,-10.67,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: