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TargetNeutrophil collagenase
LigandBDBM50062302
Substrate/Competitorn/a
Meas. Tech.ChEMBL_105205 (CHEMBL713844)
Ki 0.56±n/a nM
Citation Levy, DELapierre, FLiang, WYe, WLange, CWLi, XGrobelny, DCasabonne, MTyrrell, DHolme, KNadzan, AGalardy, RE Matrix metalloproteinase inhibitors: a structure-activity study. J Med Chem41:199-223 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neutrophil collagenase
Name:Neutrophil collagenase
Synonyms:CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:Enzyme
Mol. Mass.:53413.48
Organism:Homo sapiens (Human)
Description:P22894
Residue:467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50062302
n/a
NameBDBM50062302
Synonyms:(R)-N*4*-Hydroxy-N*1*-{(S)-2-(1H-indol-3-yl)-1-[(thiazol-2-ylmethyl)-carbamoyl]-ethyl}-2-isobutyl-succinamide | CHEMBL71995
TypeSmall organic molecule
Emp. Form.C23H29N5O4S
Mol. Mass.471.572
SMILESCC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1nccs1
Structure
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