Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M1

Ligand

BDBM50062589

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_138688 (CHEMBL749925)

IC50

5±n/a nM

Citation

Ward, JS; Merritt, L; Calligaro, DO; Bymaster, FP; Shannon, HE; Mitch, CH; Whitesitt, C; Brunsting, D; Sheardown, MJ; Olesen, PH; Swedberg, MD; Jeppesen, L; Sauerberg, P 1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists. J Med Chem41:379-92 (1998) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M1

Name:

Muscarinic acetylcholine receptor M1

Synonyms:

ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

51390.46

Organism:

RAT

Description:

P08482

Residue:

460

Sequence:

MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

BDBM50062589

n/a

Name

BDBM50062589

Synonyms:

3-(4-Butylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyclo[2.2.2]octane | CHEMBL433867

Type

Small organic molecule

Emp. Form.

C13H21N3OS2

Mol. Mass.

299.455

SMILES

CCCCSc1nsnc1OC1CN2CCC1CC2 |(8.64,-14.44,;9.78,-13.42,;9.48,-11.91,;10.62,-10.88,;10.31,-9.38,;11.46,-8.36,;12.97,-8.68,;13.74,-7.33,;12.7,-6.19,;11.32,-6.82,;9.99,-6.05,;8.64,-6.82,;8.64,-8.36,;7.31,-9.12,;6,-8.36,;6,-6.82,;7.31,-6.04,;6.56,-7.38,;8.08,-7.78,)|

Structure