| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclic AMP-dependent transcription factor ATF-1 |
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| Ligand | BDBM50062652 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_27877 (CHEMBL640575) |
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| IC50 | 3000±n/a nM |
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| Citation |  Sullivan, RW; Bigam, CG; Erdman, PE; Palanki, MS; Anderson, DW; Goldman, ME; Ransone, LJ; Suto, MJ 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-kappa B- and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry. J Med Chem41:413-9 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclic AMP-dependent transcription factor ATF-1 |
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| Name: | Cyclic AMP-dependent transcription factor ATF-1 |
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| Synonyms: | ATF1 | ATF1_HUMAN | Activating transcription factor 1 | Cyclic AMP-dependent transcription factor ATF-1 | Protein TREB36 | cAMP-dependent transcription factor ATF-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 29236.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_27877 |
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| Residue: | 271 |
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| Sequence: | MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR
RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL
ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ
IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC
LENRVAVLENQNKTLIEELKTLKDLYSNKSV
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| BDBM50062652 |
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| n/a |
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| Name | BDBM50062652 |
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| Synonyms: | 2-Chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-methyl-amide | CHEMBL337516 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H7Cl3F3N3O |
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| Mol. Mass. | 384.568 |
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| SMILES | CN(C(=O)c1cnc(Cl)nc1C(F)(F)F)c1cc(Cl)cc(Cl)c1 |
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| Structure | 
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