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TargetActivating transcription factor 1
LigandBDBM50062668
Substrate/Competitorn/a
Meas. Tech.ChEMBL_27877
IC50 4000±n/a nM
Citation Sullivan RWBigam CGErdman PEPalanki MSAnderson DWGoldman MERansone LJSuto MJ 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-kappa B- and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry. J Med Chem 41:413-9 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Activating transcription factor 1
Name:Activating transcription factor 1
Synonyms:Cyclic AMP-dependent transcription factor ATF-1 | Protein TREB36 | cAMP-dependent transcription factor ATF-1
Type:PROTEIN
Mol. Mass.:29236.24
Organism:Homo sapiens (Human)
Description:ChEMBL_27877
Residue:271
Sequence:
MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR
RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL
ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ
IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC
LENRVAVLENQNKTLIEELKTLKDLYSNKSV
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BDBM50062668
n/a
NameBDBM50062668
Synonyms:2-Piperidin-1-yl-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide | CHEMBL335655
TypeSmall organic molecule
Emp. Form.C17H15Cl2F3N4O
Mol. Mass.419.228
SMILESFC(F)(F)c1nc(ncc1C(=O)Nc1cc(Cl)cc(Cl)c1)N1CCCCC1
Structure
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