Reaction Details | |||
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Target | D(2) dopamine receptor | ||
Ligand | BDBM50063285 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_60370 (CHEMBL672206) | ||
Ki | 6±n/a nM | ||
Citation | Wustrow, D; Belliotti, T; Glase, S; Kesten, SR; Johnson, D; Colbry, N; Rubin, R; Blackburn, A; Akunne, H; Corbin, A; Davis, MD; Georgic, L; Whetzel, S; Zoski, K; Heffner, T; Pugsley, T; Wise, L Aminopyrimidines with high affinity for both serotonin and dopamine receptors. J Med Chem41:760-71 (1998) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
D(2) dopamine receptor | |||
Name: | D(2) dopamine receptor | ||
Synonyms: | D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2 | ||
Type: | Cell-surface receptors | ||
Mol. Mass.: | 50647.10 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P14416 | ||
Residue: | 443 | ||
Sequence: |
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BDBM50063285 | |||
n/a | |||
Name | BDBM50063285 | ||
Synonyms: | CHEMBL165056 | Pyrimidin-2-yl-(4-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-cyclohexyl)-amine | ||
Type | Small organic molecule | ||
Emp. Form. | C23H30F3N5 | ||
Mol. Mass. | 433.513 | ||
SMILES | FC(F)(F)c1cccc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)Nc2ncccn2)CC1 |wU:19.23,wD:16.16,(20.01,-4.08,;18.46,-4.18,;17.62,-2.89,;19.63,-5.21,;17.78,-5.56,;18.62,-6.85,;17.92,-8.23,;16.4,-8.3,;15.56,-7.01,;16.24,-5.65,;14.01,-7.1,;13.33,-8.48,;11.79,-8.55,;10.94,-7.27,;9.4,-7.34,;8.55,-6.05,;7.01,-6.12,;6.17,-4.83,;4.64,-4.9,;3.92,-6.28,;4.76,-7.57,;6.31,-7.5,;2.37,-6.35,;1.53,-5.04,;.01,-5.14,;-.84,-3.82,;-.13,-2.44,;1.41,-2.37,;2.26,-3.68,;11.65,-5.89,;13.17,-5.82,)| | ||
Structure |