Reaction Details | |||
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Target | 5-hydroxytryptamine receptor 1A | ||
Ligand | BDBM50063296 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1451 (CHEMBL616575) | ||
Ki | 3.5±n/a nM | ||
Citation | Wustrow, D; Belliotti, T; Glase, S; Kesten, SR; Johnson, D; Colbry, N; Rubin, R; Blackburn, A; Akunne, H; Corbin, A; Davis, MD; Georgic, L; Whetzel, S; Zoski, K; Heffner, T; Pugsley, T; Wise, L Aminopyrimidines with high affinity for both serotonin and dopamine receptors. J Med Chem41:760-71 (1998) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 1A | |||
Name: | 5-hydroxytryptamine receptor 1A | ||
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 46445.29 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | Binding assays were performed using rat hippocampal membranes. | ||
Residue: | 422 | ||
Sequence: |
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BDBM50063296 | |||
n/a | |||
Name | BDBM50063296 | ||
Synonyms: | CHEMBL165679 | {4-[2-(4-Phenyl-piperazin-1-yl)-ethyl]-cyclohexyl}-pyrimidin-2-yl-amine | ||
Type | Small organic molecule | ||
Emp. Form. | C22H31N5 | ||
Mol. Mass. | 365.515 | ||
SMILES | C(CN1CCN(CC1)c1ccccc1)[C@H]1CC[C@@H](CC1)Nc1ncccn1 |wU:17.22,wD:14.15,(9.21,-6.02,;10.05,-7.32,;11.59,-7.24,;12.43,-8.53,;13.97,-8.45,;14.66,-7.08,;13.82,-5.79,;12.29,-5.86,;16.2,-6.99,;17.03,-8.27,;18.56,-8.18,;19.26,-6.83,;18.41,-5.53,;16.88,-5.63,;7.68,-6.1,;6.84,-4.81,;5.31,-4.88,;4.6,-6.26,;5.44,-7.54,;6.98,-7.47,;3.06,-6.33,;2.22,-5.03,;.7,-5.11,;-.14,-3.81,;.56,-2.44,;2.1,-2.37,;2.94,-3.67,)| | ||
Structure |