Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 1A | ||
| Ligand | BDBM50063294 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1451 (CHEMBL616575) | ||
| Ki | 8.6±n/a nM | ||
| Citation |  Wustrow, D; Belliotti, T; Glase, S; Kesten, SR; Johnson, D; Colbry, N; Rubin, R; Blackburn, A; Akunne, H; Corbin, A; Davis, MD; Georgic, L; Whetzel, S; Zoski, K; Heffner, T; Pugsley, T; Wise, L Aminopyrimidines with high affinity for both serotonin and dopamine receptors. J Med Chem41:760-71 (1998) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 1A | |||
| Name: | 5-hydroxytryptamine receptor 1A | ||
| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 46445.29 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | Binding assays were performed using rat hippocampal membranes. | ||
| Residue: | 422 | ||
| Sequence: |
| ||
| BDBM50063294 | |||
| n/a | |||
| Name | BDBM50063294 | ||
| Synonyms: | CHEMBL349980 | Pyrimidin-2-yl-{4-[2-(4-pyrimidin-2-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H29N7 | ||
| Mol. Mass. | 367.4912 | ||
| SMILES | C(CN1CCN(CC1)c1ncccn1)[C@H]1CC[C@@H](CC1)Nc1ncccn1 |wU:17.22,wD:14.15,(9.2,-6.02,;10.04,-7.31,;11.58,-7.23,;12.42,-8.52,;13.96,-8.45,;14.65,-7.08,;13.82,-5.78,;12.28,-5.86,;16.19,-6.98,;17.01,-8.27,;18.55,-8.17,;19.24,-6.82,;18.39,-5.54,;16.87,-5.63,;7.67,-6.1,;6.83,-4.81,;5.3,-4.88,;4.6,-6.25,;5.43,-7.54,;6.97,-7.47,;3.06,-6.31,;2.22,-5.02,;.7,-5.11,;-.13,-3.81,;.57,-2.43,;2.11,-2.36,;2.94,-3.66,)| | ||
| Structure | 
| ||