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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 1A | ||
| Ligand | BDBM50063289 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1451 (CHEMBL616575) | ||
| Ki | 16±n/a nM | ||
| Citation |  Wustrow, D; Belliotti, T; Glase, S; Kesten, SR; Johnson, D; Colbry, N; Rubin, R; Blackburn, A; Akunne, H; Corbin, A; Davis, MD; Georgic, L; Whetzel, S; Zoski, K; Heffner, T; Pugsley, T; Wise, L Aminopyrimidines with high affinity for both serotonin and dopamine receptors. J Med Chem41:760-71 (1998) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 1A | |||
| Name: | 5-hydroxytryptamine receptor 1A | ||
| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 46445.29 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | Binding assays were performed using rat hippocampal membranes. | ||
| Residue: | 422 | ||
| Sequence: |
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| BDBM50063289 | |||
| n/a | |||
| Name | BDBM50063289 | ||
| Synonyms: | CHEMBL165140 | {4-[3-(4-Phenyl-piperazin-1-yl)-propyl]-cyclohexyl}-pyrimidin-2-yl-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H33N5 | ||
| Mol. Mass. | 379.5416 | ||
| SMILES | C(C[C@H]1CC[C@@H](CC1)Nc1ncccn1)CN1CCN(CC1)c1ccccc1 |wU:5.8,wD:2.1,(7.79,-8.8,;6.25,-8.89,;5.4,-7.59,;6.11,-6.22,;5.26,-4.94,;3.72,-5.01,;3.03,-6.39,;3.87,-7.7,;2.88,-3.72,;3.56,-2.34,;2.72,-1.06,;3.42,.32,;4.97,.4,;5.81,-.89,;5.11,-2.27,;8.63,-10.11,;10.18,-10.01,;11.02,-11.32,;12.56,-11.24,;13.25,-9.86,;12.41,-8.56,;10.88,-8.64,;14.79,-9.78,;15.63,-11.07,;17.16,-10.97,;17.86,-9.61,;16.99,-8.31,;15.47,-8.41,)| | ||
| Structure | 
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