| Reaction Details |
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 | Report a problem with these data |
| Target | Complement C1r subcomponent |
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| Ligand | BDBM50063723 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_40165 (CHEMBL655960) |
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| IC50 | 1500±n/a nM |
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| Citation |  Hays, SJ; Caprathe, BW; Gilmore, JL; Amin, N; Emmerling, MR; Michael, W; Nadimpalli, R; Nath, R; Raser, KJ; Stafford, D; Watson, D; Wang, K; Jaen, JC 2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease. J Med Chem41:1060-7 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Complement C1r subcomponent |
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| Name: | Complement C1r subcomponent |
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| Synonyms: | C1R | C1R_HUMAN | Complement C1r | Complement C1r subcomponent |
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| Type: | Enzyme |
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| Mol. Mass.: | 80113.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00736 |
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| Residue: | 705 |
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| Sequence: | MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVF
QQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDF
SNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGY
ELQEDTHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPF
DIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKL
RYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQD
DGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSR
ESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVF
TNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRV
SVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVME
EKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAV
RDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED
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| BDBM50063723 |
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| n/a |
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| Name | BDBM50063723 |
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| Synonyms: | 2-(2-Iodo-phenylamino)-7-methyl-benzo[d][1,3]oxazin-4-one | CHEMBL10248 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11IN2O2 |
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| Mol. Mass. | 378.1645 |
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| SMILES | Cc1ccc2c(c1)nc(Nc1ccccc1I)oc2=O |
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| Structure | 
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