| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50064007 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_196509 (CHEMBL798323) |
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| IC50 | 179±n/a nM |
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| Citation |  Wishka, DG; Graber, DR; Kopta, LA; Olmsted, RA; Friis, JM; Hosley, JD; Adams, WJ; Seest, EP; Castle, TM; Dolak, LA; Keiser, BJ; Yagi, Y; Jeganathan, A; Schlachter, ST; Murphy, MJ; Cleek, GJ; Nugent, RA; Poppe, SM; Swaney, SM; Han, F; Watt, W; White, WL; Poel, TJ; Thomas, RC; Morris, J (-)-6-Chloro-2-[(1-furo[2, 3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor. J Med Chem41:1357-60 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50064007 |
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| n/a |
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| Name | BDBM50064007 |
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| Synonyms: | 6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANYL)-PYRIMIDIN-4-YLAMINE | 6-Chloro-2-((S)-1-furo[2,3-c]pyridin-5-yl-ethylsulfanyl)-pyrimidin-4-ylamine | CHEMBL280541 | PNU-142721 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H11ClN4OS |
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| Mol. Mass. | 306.771 |
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| SMILES | C[C@H](Sc1nc(N)cc(Cl)n1)c1cc2ccoc2cn1 |
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| Structure | 
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