Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50064171 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_200978 (CHEMBL802065) |
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Ki | 0.62±n/a nM |
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Citation | Quaglia, W; Giannella, M; Piergentili, A; Pigini, M; Brasili, L; Di Toro, R; Rossetti, L; Spampinato, S; Melchiorre, C 1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand. J Med Chem41:1557-60 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50064171 |
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n/a |
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Name | BDBM50064171 |
Synonyms: | 1'-benzylspiro[3,4-dihydro-2H-chromene-2,4'-(hexahydropyridine)] | 1'-benzylspiro[chroman-2,4'-piperidine] | CHEMBL38634 |
Type | Small organic molecule |
Emp. Form. | C20H23NO |
Mol. Mass. | 293.4027 |
SMILES | C(N1CCC2(CC1)CCc1ccccc1O2)c1ccccc1 |
Structure |
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