Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetV-type proton ATPase 116 kDa subunit a 1
LigandBDBM50064182
Substrate/Competitorn/a
Meas. Tech.ChEMBL_210946 (CHEMBL813070)
IC50 80±n/a nM
Citation Gagliardi, SNadler, GConsolandi, EParini, CMorvan, MLegave, MNBelfiore, PZocchetti, AClarke, GDJames, INambi, PGowen, MFarina, C 5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity. J Med Chem41:1568-73 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
V-type proton ATPase 116 kDa subunit a 1
Name:V-type proton ATPase 116 kDa subunit a 1
Synonyms:ATP6V0A1 | VPP1_CHICK | Vacuolar H(+)-transporting ATPase 116 kDa subunit, a1 isoform
Type:PROTEIN
Mol. Mass.:95982.67
Organism:Gallus gallus
Description:ChEMBL_210941
Residue:838
Sequence:
MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEE
MDRKLRFVEKEIKKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKR
NFLELTELKFILRKTQQFFDEMADPDLLEESSSLLEPSEMGRGAPLRLGFVAGVINRERI
PTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGF
RASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKM
KAIYHTLNLCNIDVTQKCLSAEVWCPVADLDSIQFALRRGTEHSGSTVPSILNRMQTNQT
PPTYNKTNKFTCGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLIA
IWMVLRESRILSQKSDNEMFSTVFSGRYIILLMGLFSTYTGLIYNDCFSKSLNMFGSSWS
VRPMFSKANWSDELLKTTPLLQLDPAEAGVFGGPYPFGIDPIWNIANNKLAFLNSFKMKM
SVILGIIHMLFGVMLSLLNHIYFKKPLNIYLGFIPEMIFMSSLFGYLVILIFYKWTAYDA
HTSKEAPSPLIHFINMFLFSYGDTSNKMLYRGQKGIQCFLVVVALLCVPWMLVAKPLVLR
HQYLRRKHLGTHNFGGIRVGNGPTEEDAEIIQHDQLSTHSEEGEEPTEDEVFDFADTVVY
QAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHTGLSVRSLAGGFGLVFIF
AAFATLTVAILLVMEGLSAFLHALRLHWIEFQNKFYTGTGFKFLPFSFDPIREGKFDD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50064182
n/a
NameBDBM50064182
Synonyms:(2Z,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-penta-2,4-dienoic acid (2,2,6,6-tetramethyl-piperidin-4-yl)-amide | CHEMBL449696
TypeSmall organic molecule
Emp. Form.C23H29Cl2N3O2
Mol. Mass.450.401
SMILESCO\C(=C/C=C/c1cc2cc(Cl)c(Cl)cc2[nH]1)C(=O)NC1CC(C)(C)NC(C)(C)C1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: