| Reaction Details |
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 | Report a problem with these data |
| Target | V-type proton ATPase 116 kDa subunit a 1 |
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| Ligand | BDBM50064184 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210946 (CHEMBL813070) |
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| IC50 | 100±n/a nM |
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| Citation |  Gagliardi, S; Nadler, G; Consolandi, E; Parini, C; Morvan, M; Legave, MN; Belfiore, P; Zocchetti, A; Clarke, GD; James, I; Nambi, P; Gowen, M; Farina, C 5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity. J Med Chem41:1568-73 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| V-type proton ATPase 116 kDa subunit a 1 |
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| Name: | V-type proton ATPase 116 kDa subunit a 1 |
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| Synonyms: | ATP6V0A1 | VPP1_CHICK | Vacuolar H(+)-transporting ATPase 116 kDa subunit, a1 isoform |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95982.67 |
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| Organism: | Gallus gallus |
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| Description: | ChEMBL_210941 |
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| Residue: | 838 |
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| Sequence: | MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEE
MDRKLRFVEKEIKKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKR
NFLELTELKFILRKTQQFFDEMADPDLLEESSSLLEPSEMGRGAPLRLGFVAGVINRERI
PTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGF
RASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKM
KAIYHTLNLCNIDVTQKCLSAEVWCPVADLDSIQFALRRGTEHSGSTVPSILNRMQTNQT
PPTYNKTNKFTCGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLIA
IWMVLRESRILSQKSDNEMFSTVFSGRYIILLMGLFSTYTGLIYNDCFSKSLNMFGSSWS
VRPMFSKANWSDELLKTTPLLQLDPAEAGVFGGPYPFGIDPIWNIANNKLAFLNSFKMKM
SVILGIIHMLFGVMLSLLNHIYFKKPLNIYLGFIPEMIFMSSLFGYLVILIFYKWTAYDA
HTSKEAPSPLIHFINMFLFSYGDTSNKMLYRGQKGIQCFLVVVALLCVPWMLVAKPLVLR
HQYLRRKHLGTHNFGGIRVGNGPTEEDAEIIQHDQLSTHSEEGEEPTEDEVFDFADTVVY
QAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHTGLSVRSLAGGFGLVFIF
AAFATLTVAILLVMEGLSAFLHALRLHWIEFQNKFYTGTGFKFLPFSFDPIREGKFDD
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| BDBM50064184 |
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| n/a |
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| Name | BDBM50064184 |
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| Synonyms: | (2Z,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-penta-2,4-dienoic acid ((1S,5R)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide | CHEMBL288419 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25Cl2N3O2 |
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| Mol. Mass. | 434.359 |
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| SMILES | CO\C(=C/C=C/c1cc2cc(Cl)c(Cl)cc2[nH]1)C(=O)NC1C[C@@H]2CC[C@H](C1)N2C |THB:28:27:20.21.26:23.24| |
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| Structure | 
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