| Reaction Details |
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 | Report a problem with these data |
| Target | V-type proton ATPase subunit S1 |
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| Ligand | BDBM50064183 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210943 (CHEMBL812903) |
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| IC50 | 1900±n/a nM |
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| Citation |  Gagliardi, S; Nadler, G; Consolandi, E; Parini, C; Morvan, M; Legave, MN; Belfiore, P; Zocchetti, A; Clarke, GD; James, I; Nambi, P; Gowen, M; Farina, C 5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity. J Med Chem41:1568-73 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| V-type proton ATPase subunit S1 |
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| Name: | V-type proton ATPase subunit S1 |
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| Synonyms: | ATP6AP1 | ATP6IP1 | ATP6S1 | Protein XAP-3 | V-ATPase Ac45 subunit | V-ATPase S1 accessory protein | V-ATPase subunit S1 | V-type proton ATPase subunit S1 | VAS1_HUMAN | VATPS1 | Vacuolar ATP synthase subunit S1 | Vacuolar proton pump subunit S1 | XAP3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52022.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_215469 |
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| Residue: | 470 |
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| Sequence: | MMAAMATARVRMGPRCAQALWRMPWLPVFLSLAAAAAAAAAEQQVPLVLWSSDRDLWAPA
ADTHEGHITSDLQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNL
ENALDLAPSSLVLPAVDWYAVSTLTTYLQEKLGASPLHVDLATLRELKLNASLPALLLIR
LPYTASSGLMAPREVLTGNDEVIGQVLSTLKSEDVPYTAALTAVRPSRVARDVAVVAGGL
GRQLLQKQPVSPVIHPPVSYNDTAPRILFWAQNFSVAYKDQWEDLTPLTFGVQELNLTGS
FWNDSFARLSLTYERLFGTTVTFKFILANRLYPVSARHWFTMERLEVHSNGSVAYFNASQ
VTGPSIYSFHCEYVSSLSKKGSLLVARTQPSPWQMMLQDFQIQAFNVMGEQFSYASDCAS
FFSPGIWMGLLTSLFMLFIFTYGLHMILSLKTMDRFDDHKGPTISLTQIV
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| BDBM50064183 |
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| n/a |
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| Name | BDBM50064183 |
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| Synonyms: | (2E,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-penta-2,4-dienoic acid methyl ester | CHEMBL39097 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13Cl2NO3 |
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| Mol. Mass. | 326.175 |
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| SMILES | COC(=O)C(\OC)=C/C=C/c1cc2cc(Cl)c(Cl)cc2[nH]1 |
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| Structure | 
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