| Reaction Details |
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 | Report a problem with these data |
| Target | V-type proton ATPase subunit B, kidney isoform |
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| Ligand | BDBM50064180 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210947 (CHEMBL813071) |
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| IC50 | 370±n/a nM |
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| Citation |  Gagliardi, S; Nadler, G; Consolandi, E; Parini, C; Morvan, M; Legave, MN; Belfiore, P; Zocchetti, A; Clarke, GD; James, I; Nambi, P; Gowen, M; Farina, C 5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity. J Med Chem41:1568-73 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| V-type proton ATPase subunit B, kidney isoform |
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| Name: | V-type proton ATPase subunit B, kidney isoform |
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| Synonyms: | ATP6B1 | ATP6V1B1 | VATB | VATB1_HUMAN | VPP3 | Vacuolar ATP synthase subunit B, kidney isoform |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56825.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_210947 |
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| Residue: | 513 |
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| Sequence: | MAMEIDSRPGGLPGSSCNLGAAREHMQAVTRNYITHPRVTYRTVCSVNGPLVVLDRVKFA
QYAEIVHFTLPDGTQRSGQVLEVAGTKAIVQVFEGTSGIDARKTTCEFTGDILRTPVSED
MLGRVFNGSGKPIDKGPVVMAEDFLDINGQPINPHSRIYPEEMIQTGISPIDVMNSIARG
QKIPIFSAAGLPHNEIAAQICRQAGLVKKSKAVLDYHDDNFAIVFAAMGVNMETARFFKS
DFEQNGTMGNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEA
LREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRGGSITQIPILTMPNDDITHPIP
DLTGFITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYACY
AIGKDVQAMKAVVGEEALTSEDLLYLEFLQKFEKNFINQGPYENRSVFESLDLGWKLLRI
FPKEMLKRIPQAVIDEFYSREGALQDLAPDTAL
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| BDBM50064180 |
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| n/a |
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| Name | BDBM50064180 |
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| Synonyms: | (2Z,4E)-5-(5,6-Dichloro-1H-indol-2-yl)-2-methoxy-penta-2,4-dienoic acid [3-(4-pyrimidin-2-yl-piperazin-1-yl)-propyl]-amide | CHEMBL41588 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28Cl2N6O2 |
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| Mol. Mass. | 515.435 |
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| SMILES | CO\C(=C/C=C/c1cc2cc(Cl)c(Cl)cc2[nH]1)C(=O)NCCCN1CCN(CC1)c1ncccn1 |
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| Structure | 
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