Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50064198 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_158768 (CHEMBL772929) |
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Ki | 80±n/a nM |
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Citation | Martin, SF; Dorsey, GO; Gane, T; Hillier, MC; Kessler, H; Baur, M; Mathä, B; Erickson, JW; Bhat, TN; Munshi, S; Gulnik, SV; Topol, IA Cyclopropane-derived peptidomimetics. Design, synthesis, evaluation, and structure of novel HIV-1 protease inhibitors. J Med Chem41:1581-97 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50064198 |
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n/a |
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Name | BDBM50064198 |
Synonyms: | 1N-{1-benzyl-4-[2,2-dimethyl-3-methyl(2-pyridylmethyl)carbamoylcyclopropylcarboxamido]-2,3-dihydroxy-5-phenylpentyl}-2N,3,3-trimethyl-2N-(2-pyridylmethyl)-1,2-cyclopropanedicarboxamide | CHEMBL290847 |
Type | Small organic molecule |
Emp. Form. | C46H56N6O6 |
Mol. Mass. | 788.9734 |
SMILES | CN(Cc1ccccn1)C(=O)[C@H]1[C@H](C(=O)N[C@@H](Cc2ccccc2)[C@@H](O)[C@H](O)[C@H](Cc2ccccc2)NC(=O)[C@H]2[C@H](C(=O)N(C)Cc3ccccn3)C2(C)C)C1(C)C |
Structure |
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