Ki Summary

Reaction Details

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Target

Retinoic acid receptor beta

Ligand

BDBM50064250

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_195641 (CHEMBL795959)

IC50

49±n/a nM

Citation

Muccio, DD; Brouillette, WJ; Breitman, TR; Taimi, M; Emanuel, PD; Zhang, X; Chen, G; Sani, BP; Venepally, P; Reddy, L; Alam, M; Simpson-Herren, L; Hill, DL Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias. J Med Chem41:1679-87 (1998) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Retinoic acid receptor beta

Name:

Retinoic acid receptor beta

Synonyms:

Nr1b2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RARB_MOUSE | Rarb

Type:

PROTEIN

Mol. Mass.:

53344.93

Organism:

Mus musculus

Description:

ChEMBL_195641

Residue:

482

Sequence:

MSTSSHACPVPAVRGHMTHYPAAPYPLLFPPVIRGLSLPPLHGLHGHPPPSGCSTPSPAS
VGQACQRTTGGSQFAASTKWTPSLNAAIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQD
KSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGM
SKESVRNDRNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSS
ADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRI
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAIC
LICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAE
RVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNIAEHSPSVSPSSVENSGVSQSPL
LQ

BDBM50064250

n/a

Name

BDBM50064250

Synonyms:

(2E,4E,6E)-8-[3,4-Dihydro-2H-naphthalen-(1E)-ylidene]-3,7-dimethyl-octa-2,4,6-trienoic acid | 3,7-dimethyl-8-(1,2,3,4-tetrahydro-1-naphthalenyliden)-(2E,4E,6E)-2,4,6-octatrienoic acid | CHEMBL46397

Type

Small organic molecule

Emp. Form.

C20H22O2

Mol. Mass.

294.3875

SMILES

C\C(\C=C\C=C(/C)\C=C1/CCCc2ccccc12)=C/C(O)=O

Structure