| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50064317 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63486 (CHEMBL674777) |
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| Ki | 51±n/a nM |
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| KOFF | 0.0000515 s-1 |
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| KON | 1010 M-1s-1 |
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| Citation |  Gütschow, M; Neumann, U Novel thieno[2,3-d][1,3]oxazin-4-ones as inhibitors of human leukocyte elastase. J Med Chem41:1729-40 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50064317 |
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| n/a |
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| Name | BDBM50064317 |
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| Synonyms: | 2-Isobutoxy-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d][1,3]oxazin-4-one | CHEMBL298402 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17NO3S |
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| Mol. Mass. | 279.355 |
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| SMILES | CC(C)COc1nc2sc3CCCCc3c2c(=O)o1 |
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| Structure | 
|
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