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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Platelet-derived growth factor receptor alpha/beta | ||
| Ligand | BDBM3095 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_158357 (CHEMBL770468) | ||
| IC50 | 103±n/a nM | ||
| Citation |  Trumpp-Kallmeyer, S; Rubin, JR; Humblet, C; Hamby, JM; Hollis Showalter, HD Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors. J Med Chem41:1752-63 (1998) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Platelet-derived growth factor receptor alpha/beta | |||
| Name: | Platelet-derived growth factor receptor alpha/beta | ||
| Synonyms: | PDGFR-beta/Platelet-derived growth factor receptor alpha | Platelet-derived growth factor receptor | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of EBI is 454 | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Platelet-derived growth factor receptor beta | ||
| Synonyms: | 2.7.10.1 | Beta platelet-derived growth factor receptor | Beta-type platelet-derived growth factor receptor | CD140 antigen-like family member B | CD140b antigen | CD_antigen=CD140b | PDGF-R-beta | PDGFR-1 | PDGFR-beta | PGFRB_MOUSE | Pdgfr | Pdgfr1 | Pdgfrb | Platelet-Derived Growth Factor Receptor, beta | Platelet-derived growth factor receptor | Platelet-derived growth factor receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 122771.00 | ||
| Organism: | Mus musculus (mouse) | ||
| Description: | P05622 | ||
| Residue: | 1098 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Platelet-derived growth factor receptor alpha | ||
| Synonyms: | PGFRA_MOUSE | Pdgfra | Platelet-derived growth factor receptor | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 122646.66 | ||
| Organism: | Mus musculus | ||
| Description: | EBI_12628 | ||
| Residue: | 1089 | ||
| Sequence: |
| ||
| BDBM3095 | |||
| n/a | |||
| Name | BDBM3095 | ||
| Synonyms: | 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 62 | 6-(2,6-Dichlorophenyl)-2-[3-(2-diethylaminoethoxy)phenylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, Dihydrochloride | 6-(2,6-dichlorophenyl)-2-({3-[2-(diethylamino)ethoxy]phenyl}amino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL297523 | PD 166285 analog | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H27Cl2N5O2 | ||
| Mol. Mass. | 512.431 | ||
| SMILES | CCN(CC)CCOc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 |(-13.08,-10.99,;-11.59,-10.59,;-10.82,-9.26,;-9.48,-10.03,;-8.4,-8.94,;-11.59,-7.93,;-10.82,-6.59,;-10.82,-5.05,;-9.48,-4.28,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,)| | ||
| Structure | 
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