Reaction Details | |||
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Target | Platelet-derived growth factor receptor alpha/beta | ||
Ligand | BDBM3101 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_158357 (CHEMBL770468) | ||
IC50 | 115±n/a nM | ||
Citation | Trumpp-Kallmeyer, S; Rubin, JR; Humblet, C; Hamby, JM; Hollis Showalter, HD Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors. J Med Chem41:1752-63 (1998) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Platelet-derived growth factor receptor alpha/beta | |||
Name: | Platelet-derived growth factor receptor alpha/beta | ||
Synonyms: | PDGFR-beta/Platelet-derived growth factor receptor alpha | Platelet-derived growth factor receptor | ||
Type: | n/a | ||
Mol. Mass.: | n/a | ||
Description: | ASSAY_ID of EBI is 454 | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Platelet-derived growth factor receptor beta | ||
Synonyms: | 2.7.10.1 | Beta platelet-derived growth factor receptor | Beta-type platelet-derived growth factor receptor | CD140 antigen-like family member B | CD140b antigen | CD_antigen=CD140b | PDGF-R-beta | PDGFR-1 | PDGFR-beta | PGFRB_MOUSE | Pdgfr | Pdgfr1 | Pdgfrb | Platelet-Derived Growth Factor Receptor, beta | Platelet-derived growth factor receptor | Platelet-derived growth factor receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 122771.00 | ||
Organism: | Mus musculus (mouse) | ||
Description: | P05622 | ||
Residue: | 1098 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Platelet-derived growth factor receptor alpha | ||
Synonyms: | PGFRA_MOUSE | Pdgfra | Platelet-derived growth factor receptor | ||
Type: | PROTEIN | ||
Mol. Mass.: | 122646.66 | ||
Organism: | Mus musculus | ||
Description: | EBI_12628 | ||
Residue: | 1089 | ||
Sequence: |
| ||
BDBM3101 | |||
n/a | |||
Name | BDBM3101 | ||
Synonyms: | 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 68 | 6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL51283 | PD 166285 analog | ||
Type | Small organic molecule | ||
Emp. Form. | C25H24Cl2N6O | ||
Mol. Mass. | 495.404 | ||
SMILES | CN1CCN(CC1)c1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-8.03,-11.21,;-8.03,-9.67,;-9.39,-8.95,;-9.45,-7.41,;-8.15,-6.59,;-6.79,-7.31,;-6.73,-8.85,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)| | ||
Structure |