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TargetKappa-type opioid receptor
LigandBDBM50064516
Substrate/Competitorn/a
Meas. Tech.ChEMBL_146678 (CHEMBL753170)
Ki 1150±n/a nM
Citation Thomas, JBMascarella, SWRothman, RBPartilla, JSXu, HMcCullough, KBDersch, CMCantrell, BEZimmerman, DMCarroll, FI Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists. J Med Chem41:1980-90 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kappa-type opioid receptor
Name:Kappa-type opioid receptor
Synonyms:Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42744.99
Organism:Cavia porcellus (domestic guinea pig)
Description:P41144
Residue:380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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  Blast E-value cutoff:
BDBM50064516
n/a
NameBDBM50064516
Synonyms:3-[(3R,4R)-1-(3-Hydroxy-cyclohexyl)-3,4-dimethyl-piperidin-4-yl]-phenol | CHEMBL60657
TypeSmall organic molecule
Emp. Form.C19H29NO2
Mol. Mass.303.4391
SMILESC[C@H]1CN(CC[C@@]1(C)c1cccc(O)c1)C1CCCC(O)C1
Structure
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